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The highest dose administered in these reports (seventy five mg/kg/day) was, over a mg/m2 basis, about such as the utmost encouraged daily human oral dose (MRHD) in mice and about twice the MRHD in rats.
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Nonclinical information are suggestive of a probable potentiation of aspirin-relevant fetal toxicity when combined with dipyridamole (see Facts). The estimated history risk of major beginning defects and miscarriage to the indicated population is not known.
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Within a analyze conducted using an intravenous formulation of dipyridamole, clients with gentle to extreme hepatic insufficiency showed no modify in plasma concentrations of dipyridamole but confirmed a rise in the pharmacologically inactive monoglucuronide metabolite. Dipyridamole might be dosed with out restriction as long as there's no proof of hepatic failure.
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